AustralieFrV1, Main, Exploration, bibRecord, 004662

High-fat diet alters gut microbiota physiology in mice

Identifieur interne : 004662 ( Main/Exploration ); précédent : 004661; suivant : 004663

High-fat diet alters gut microbiota physiology in mice

Auteurs : Hannelore Daniel [Allemagne] ; Amin Moghaddas Gholami [Allemagne] ; David Berry [Autriche] ; Charles Desmarchelier [Allemagne] ; Hannes Hahne [Allemagne] ; Gunnar Loh [Allemagne] ; Stanislas Mondot [France, Australie] ; Patricia Lepage [France] ; Michael Rothballer [Allemagne] ; Alesia Walker [Allemagne] ; Christoph Böhm [Autriche] ; Mareike Wenning [Allemagne] ; Michael Wagner [Autriche] ; Michael Blaut [Allemagne] ; Philippe Schmitt-Kopplin [Allemagne] ; Bernhard Kuster [Allemagne] ; Dirk Haller [Allemagne] ; Thomas Clavel [Allemagne]

Source :

The ISME Journal [ 1751-7362 ] ; 2013.

RBID : PMC:3906816

Descripteurs français

KwdFr :
- ARN ribosomique 16S (génétique), Alimentation riche en graisse, Animaux, Bactéries (), Bactéries (génétique), Biodiversité, Caecum (microbiologie), Microbiote (physiologie), Mâle, Métabolome, Obésité (microbiologie), Phénomènes physiologiques bactériens, Protéome, Souris, Souris de lignée C57BL, Tube digestif (microbiologie).
MESH :
- génétique : ARN ribosomique 16S, Bactéries.
- microbiologie : Caecum, Obésité, Tube digestif.
- physiologie : Microbiote.
- Alimentation riche en graisse, Animaux, Bactéries, Biodiversité, Mâle, Métabolome, Phénomènes physiologiques bactériens, Protéome, Souris, Souris de lignée C57BL.

English descriptors

KwdEn :
- Animals, Bacteria (classification), Bacteria (genetics), Bacterial Physiological Phenomena, Biodiversity, Cecum (microbiology), Diet, High-Fat, Gastrointestinal Tract (microbiology), Male, Metabolome, Mice, Mice, Inbred C57BL, Microbiota (physiology), Obesity (microbiology), Proteome, RNA, Ribosomal, 16S (genetics).
MESH :
- chemical , genetics : RNA, Ribosomal, 16S.
- chemical : Proteome.
- classification : Bacteria.
- genetics : Bacteria.
- microbiology : Cecum, Gastrointestinal Tract, Obesity.
- physiology : Microbiota.
- Animals, Bacterial Physiological Phenomena, Biodiversity, Diet, High-Fat, Male, Metabolome, Mice, Mice, Inbred C57BL.

Abstract

The intestinal microbiota is known to regulate host energy homeostasis and can be influenced by high-calorie diets. However, changes affecting the ecosystem at the functional level are still not well characterized. We measured shifts in cecal bacterial communities in mice fed a carbohydrate or high-fat (HF) diet for 12 weeks at the level of the following: (i) diversity and taxa distribution by high-throughput 16S ribosomal RNA gene sequencing; (ii) bulk and single-cell chemical composition by Fourier-transform infrared- (FT-IR) and Raman micro-spectroscopy and (iii) metaproteome and metabolome via high-resolution mass spectrometry. High-fat diet caused shifts in the diversity of dominant gut bacteria and altered the proportion of Ruminococcaceae (decrease) and Rikenellaceae (increase). FT-IR spectroscopy revealed that the impact of the diet on cecal chemical fingerprints is greater than the impact of microbiota composition. Diet-driven changes in biochemical fingerprints of members of the Bacteroidales and Lachnospiraceae were also observed at the level of single cells, indicating that there were distinct differences in cellular composition of dominant phylotypes under different diets. Metaproteome and metabolome analyses based on the occurrence of 1760 bacterial proteins and 86 annotated metabolites revealed distinct HF diet-specific profiles. Alteration of hormonal and anti-microbial networks, bile acid and bilirubin metabolism and shifts towards amino acid and simple sugars metabolism were observed. We conclude that a HF diet markedly affects the gut bacterial ecosystem at the functional level.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906816

DOI: 10.1038/ismej.2013.155
PubMed: 24030595
PubMed Central: 3906816

Affiliations:

Allemagne, Australie, Autriche, France

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">High-fat diet alters gut microbiota physiology in mice</title>
<author><name sortKey="Daniel, Hannelore" sort="Daniel, Hannelore" uniqKey="Daniel H" first="Hannelore" last="Daniel">Hannelore Daniel</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Molecular Nutrition Unit, ZIEL-Research Center for Nutrition and Food Sciences, Technische Universität München</institution>
, Freising-Weihenstephan,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gholami, Amin Moghaddas" sort="Gholami, Amin Moghaddas" uniqKey="Gholami A" first="Amin Moghaddas" last="Gholami">Amin Moghaddas Gholami</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Proteomics and Bioanalytics, Technische Universität München</institution>
, Freising-Weihenstephan,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Berry, David" sort="Berry, David" uniqKey="Berry D" first="David" last="Berry">David Berry</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Division of Microbial Ecology, Department of Microbiology and Ecosystem Science, Faculty of Life Sciences, University of Vienna</institution>
, Vienna,<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Desmarchelier, Charles" sort="Desmarchelier, Charles" uniqKey="Desmarchelier C" first="Charles" last="Desmarchelier">Charles Desmarchelier</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Molecular Nutrition Unit, ZIEL-Research Center for Nutrition and Food Sciences, Technische Universität München</institution>
, Freising-Weihenstephan,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hahne, Hannes" sort="Hahne, Hannes" uniqKey="Hahne H" first="Hannes" last="Hahne">Hannes Hahne</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Proteomics and Bioanalytics, Technische Universität München</institution>
, Freising-Weihenstephan,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Loh, Gunnar" sort="Loh, Gunnar" uniqKey="Loh G" first="Gunnar" last="Loh">Gunnar Loh</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Gastrointestinal Microbiology, German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE)</institution>
, Nuthetal,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mondot, Stanislas" sort="Mondot, Stanislas" uniqKey="Mondot S" first="Stanislas" last="Mondot">Stanislas Mondot</name>
<affiliation wicri:level="1"><nlm:aff id="aff5"><institution>INRA/AgroParisTech, Micalis UMR1319</institution>
, Jouy-en-Josas,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff6"><institution>CSIRO Livestock Industries, Queensland Bioscience Precinct</institution>
, St Lucia,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lepage, Patricia" sort="Lepage, Patricia" uniqKey="Lepage P" first="Patricia" last="Lepage">Patricia Lepage</name>
<affiliation wicri:level="1"><nlm:aff id="aff5"><institution>INRA/AgroParisTech, Micalis UMR1319</institution>
, Jouy-en-Josas,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rothballer, Michael" sort="Rothballer, Michael" uniqKey="Rothballer M" first="Michael" last="Rothballer">Michael Rothballer</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Research Unit Plant-Microbe Interactions, Helmholtz Zentrum München</institution>
, Neuherberg,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Walker, Alesia" sort="Walker, Alesia" uniqKey="Walker A" first="Alesia" last="Walker">Alesia Walker</name>
<affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Analytical BioGeoChemistry, Helmoltz Zentrum München, Neuherberg, Germany; Chair of Analytical Food Chemistry, Technische Universität München</institution>
, Freising-Weihenstephan,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bohm, Christoph" sort="Bohm, Christoph" uniqKey="Bohm C" first="Christoph" last="Böhm">Christoph Böhm</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Division of Microbial Ecology, Department of Microbiology and Ecosystem Science, Faculty of Life Sciences, University of Vienna</institution>
, Vienna,<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wenning, Mareike" sort="Wenning, Mareike" uniqKey="Wenning M" first="Mareike" last="Wenning">Mareike Wenning</name>
<affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Microbiology, ZIEL-Research Center for Nutrition and Food Sciences, Technische Universität München</institution>
, Freising-Weihenstephan,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wagner, Michael" sort="Wagner, Michael" uniqKey="Wagner M" first="Michael" last="Wagner">Michael Wagner</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Division of Microbial Ecology, Department of Microbiology and Ecosystem Science, Faculty of Life Sciences, University of Vienna</institution>
, Vienna,<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Blaut, Michael" sort="Blaut, Michael" uniqKey="Blaut M" first="Michael" last="Blaut">Michael Blaut</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Gastrointestinal Microbiology, German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE)</institution>
, Nuthetal,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schmitt Kopplin, Philippe" sort="Schmitt Kopplin, Philippe" uniqKey="Schmitt Kopplin P" first="Philippe" last="Schmitt-Kopplin">Philippe Schmitt-Kopplin</name>
<affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Analytical BioGeoChemistry, Helmoltz Zentrum München, Neuherberg, Germany; Chair of Analytical Food Chemistry, Technische Universität München</institution>
, Freising-Weihenstephan,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kuster, Bernhard" sort="Kuster, Bernhard" uniqKey="Kuster B" first="Bernhard" last="Kuster">Bernhard Kuster</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Proteomics and Bioanalytics, Technische Universität München</institution>
, Freising-Weihenstephan,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Center for Integrated Protein Science Munich</institution>
,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Haller, Dirk" sort="Haller, Dirk" uniqKey="Haller D" first="Dirk" last="Haller">Dirk Haller</name>
<affiliation wicri:level="1"><nlm:aff id="aff11"><institution>Chair of Nutrition and Immunology, Technische Universität München</institution>
, Freising-Weihenstephan,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Clavel, Thomas" sort="Clavel, Thomas" uniqKey="Clavel T" first="Thomas" last="Clavel">Thomas Clavel</name>
<affiliation wicri:level="1"><nlm:aff id="aff11"><institution>Chair of Nutrition and Immunology, Technische Universität München</institution>
, Freising-Weihenstephan,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff12"><institution>Junior Research Group Intestinal Microbiome, ZIEL-Research Center for Nutrition and Food Sciences, Technische Universität München</institution>
, Freising-Weihenstephan,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">24030595</idno>
<idno type="pmc">3906816</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906816</idno>
<idno type="RBID">PMC:3906816</idno>
<idno type="doi">10.1038/ismej.2013.155</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">000064</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000064</idno>
<idno type="wicri:Area/Pmc/Curation">000064</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000064</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001A81</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001A81</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">003976</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003976</idno>
<idno type="wicri:Area/PubMed/Curation">003861</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003861</idno>
<idno type="wicri:Area/PubMed/Checkpoint">003861</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003861</idno>
<idno type="wicri:Area/Ncbi/Merge">001460</idno>
<idno type="wicri:Area/Ncbi/Curation">001460</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001460</idno>
<idno type="wicri:doubleKey">1751-7362:2013:Daniel H:high:fat:diet</idno>
<idno type="wicri:Area/Main/Merge">004772</idno>
<idno type="wicri:Area/Main/Curation">004662</idno>
<idno type="wicri:Area/Main/Exploration">004662</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">High-fat diet alters gut microbiota physiology in mice</title>
<author><name sortKey="Daniel, Hannelore" sort="Daniel, Hannelore" uniqKey="Daniel H" first="Hannelore" last="Daniel">Hannelore Daniel</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Molecular Nutrition Unit, ZIEL-Research Center for Nutrition and Food Sciences, Technische Universität München</institution>
, Freising-Weihenstephan,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gholami, Amin Moghaddas" sort="Gholami, Amin Moghaddas" uniqKey="Gholami A" first="Amin Moghaddas" last="Gholami">Amin Moghaddas Gholami</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Proteomics and Bioanalytics, Technische Universität München</institution>
, Freising-Weihenstephan,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Berry, David" sort="Berry, David" uniqKey="Berry D" first="David" last="Berry">David Berry</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Division of Microbial Ecology, Department of Microbiology and Ecosystem Science, Faculty of Life Sciences, University of Vienna</institution>
, Vienna,<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Desmarchelier, Charles" sort="Desmarchelier, Charles" uniqKey="Desmarchelier C" first="Charles" last="Desmarchelier">Charles Desmarchelier</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Molecular Nutrition Unit, ZIEL-Research Center for Nutrition and Food Sciences, Technische Universität München</institution>
, Freising-Weihenstephan,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hahne, Hannes" sort="Hahne, Hannes" uniqKey="Hahne H" first="Hannes" last="Hahne">Hannes Hahne</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Proteomics and Bioanalytics, Technische Universität München</institution>
, Freising-Weihenstephan,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Loh, Gunnar" sort="Loh, Gunnar" uniqKey="Loh G" first="Gunnar" last="Loh">Gunnar Loh</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Gastrointestinal Microbiology, German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE)</institution>
, Nuthetal,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mondot, Stanislas" sort="Mondot, Stanislas" uniqKey="Mondot S" first="Stanislas" last="Mondot">Stanislas Mondot</name>
<affiliation wicri:level="1"><nlm:aff id="aff5"><institution>INRA/AgroParisTech, Micalis UMR1319</institution>
, Jouy-en-Josas,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff6"><institution>CSIRO Livestock Industries, Queensland Bioscience Precinct</institution>
, St Lucia,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lepage, Patricia" sort="Lepage, Patricia" uniqKey="Lepage P" first="Patricia" last="Lepage">Patricia Lepage</name>
<affiliation wicri:level="1"><nlm:aff id="aff5"><institution>INRA/AgroParisTech, Micalis UMR1319</institution>
, Jouy-en-Josas,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rothballer, Michael" sort="Rothballer, Michael" uniqKey="Rothballer M" first="Michael" last="Rothballer">Michael Rothballer</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Research Unit Plant-Microbe Interactions, Helmholtz Zentrum München</institution>
, Neuherberg,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Walker, Alesia" sort="Walker, Alesia" uniqKey="Walker A" first="Alesia" last="Walker">Alesia Walker</name>
<affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Analytical BioGeoChemistry, Helmoltz Zentrum München, Neuherberg, Germany; Chair of Analytical Food Chemistry, Technische Universität München</institution>
, Freising-Weihenstephan,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bohm, Christoph" sort="Bohm, Christoph" uniqKey="Bohm C" first="Christoph" last="Böhm">Christoph Böhm</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Division of Microbial Ecology, Department of Microbiology and Ecosystem Science, Faculty of Life Sciences, University of Vienna</institution>
, Vienna,<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wenning, Mareike" sort="Wenning, Mareike" uniqKey="Wenning M" first="Mareike" last="Wenning">Mareike Wenning</name>
<affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Microbiology, ZIEL-Research Center for Nutrition and Food Sciences, Technische Universität München</institution>
, Freising-Weihenstephan,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wagner, Michael" sort="Wagner, Michael" uniqKey="Wagner M" first="Michael" last="Wagner">Michael Wagner</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Division of Microbial Ecology, Department of Microbiology and Ecosystem Science, Faculty of Life Sciences, University of Vienna</institution>
, Vienna,<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Blaut, Michael" sort="Blaut, Michael" uniqKey="Blaut M" first="Michael" last="Blaut">Michael Blaut</name>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Gastrointestinal Microbiology, German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE)</institution>
, Nuthetal,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schmitt Kopplin, Philippe" sort="Schmitt Kopplin, Philippe" uniqKey="Schmitt Kopplin P" first="Philippe" last="Schmitt-Kopplin">Philippe Schmitt-Kopplin</name>
<affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Analytical BioGeoChemistry, Helmoltz Zentrum München, Neuherberg, Germany; Chair of Analytical Food Chemistry, Technische Universität München</institution>
, Freising-Weihenstephan,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kuster, Bernhard" sort="Kuster, Bernhard" uniqKey="Kuster B" first="Bernhard" last="Kuster">Bernhard Kuster</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Proteomics and Bioanalytics, Technische Universität München</institution>
, Freising-Weihenstephan,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Center for Integrated Protein Science Munich</institution>
,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Haller, Dirk" sort="Haller, Dirk" uniqKey="Haller D" first="Dirk" last="Haller">Dirk Haller</name>
<affiliation wicri:level="1"><nlm:aff id="aff11"><institution>Chair of Nutrition and Immunology, Technische Universität München</institution>
, Freising-Weihenstephan,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Clavel, Thomas" sort="Clavel, Thomas" uniqKey="Clavel T" first="Thomas" last="Clavel">Thomas Clavel</name>
<affiliation wicri:level="1"><nlm:aff id="aff11"><institution>Chair of Nutrition and Immunology, Technische Universität München</institution>
, Freising-Weihenstephan,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff12"><institution>Junior Research Group Intestinal Microbiome, ZIEL-Research Center for Nutrition and Food Sciences, Technische Universität München</institution>
, Freising-Weihenstephan,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">The ISME Journal</title>
<idno type="ISSN">1751-7362</idno>
<idno type="eISSN">1751-7370</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Bacteria (classification)</term>
<term>Bacteria (genetics)</term>
<term>Bacterial Physiological Phenomena</term>
<term>Biodiversity</term>
<term>Cecum (microbiology)</term>
<term>Diet, High-Fat</term>
<term>Gastrointestinal Tract (microbiology)</term>
<term>Male</term>
<term>Metabolome</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Microbiota (physiology)</term>
<term>Obesity (microbiology)</term>
<term>Proteome</term>
<term>RNA, Ribosomal, 16S (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ARN ribosomique 16S (génétique)</term>
<term>Alimentation riche en graisse</term>
<term>Animaux</term>
<term>Bactéries ()</term>
<term>Bactéries (génétique)</term>
<term>Biodiversité</term>
<term>Caecum (microbiologie)</term>
<term>Microbiote (physiologie)</term>
<term>Mâle</term>
<term>Métabolome</term>
<term>Obésité (microbiologie)</term>
<term>Phénomènes physiologiques bactériens</term>
<term>Protéome</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
<term>Tube digestif (microbiologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA, Ribosomal, 16S</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Proteome</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Bacteria</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Bacteria</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN ribosomique 16S</term>
<term>Bactéries</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Caecum</term>
<term>Obésité</term>
<term>Tube digestif</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Cecum</term>
<term>Gastrointestinal Tract</term>
<term>Obesity</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Microbiote</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Microbiota</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Bacterial Physiological Phenomena</term>
<term>Biodiversity</term>
<term>Diet, High-Fat</term>
<term>Male</term>
<term>Metabolome</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Alimentation riche en graisse</term>
<term>Animaux</term>
<term>Bactéries</term>
<term>Biodiversité</term>
<term>Mâle</term>
<term>Métabolome</term>
<term>Phénomènes physiologiques bactériens</term>
<term>Protéome</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>The intestinal microbiota is known to regulate host energy homeostasis and can be influenced by high-calorie diets. However, changes affecting the ecosystem at the functional level are still not well characterized. We measured shifts in cecal bacterial communities in mice fed a carbohydrate or high-fat (HF) diet for 12 weeks at the level of the following: (i) diversity and taxa distribution by high-throughput 16S ribosomal RNA gene sequencing; (ii) bulk and single-cell chemical composition by Fourier-transform infrared- (FT-IR) and Raman micro-spectroscopy and (iii) metaproteome and metabolome via high-resolution mass spectrometry. High-fat diet caused shifts in the diversity of dominant gut bacteria and altered the proportion of <italic>Ruminococcaceae</italic>
 (decrease) and <italic>Rikenellaceae</italic>
 (increase). FT-IR spectroscopy revealed that the impact of the diet on cecal chemical fingerprints is greater than the impact of microbiota composition. Diet-driven changes in biochemical fingerprints of members of the <italic>Bacteroidales</italic>
 and <italic>Lachnospiraceae</italic>
 were also observed at the level of single cells, indicating that there were distinct differences in cellular composition of dominant phylotypes under different diets. Metaproteome and metabolome analyses based on the occurrence of 1760 bacterial proteins and 86 annotated metabolites revealed distinct HF diet-specific profiles. Alteration of hormonal and anti-microbial networks, bile acid and bilirubin metabolism and shifts towards amino acid and simple sugars metabolism were observed. We conclude that a HF diet markedly affects the gut bacterial ecosystem at the functional level.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Autriche</li>
<li>France</li>
</country>
</list>
<tree><country name="Allemagne"><noRegion><name sortKey="Daniel, Hannelore" sort="Daniel, Hannelore" uniqKey="Daniel H" first="Hannelore" last="Daniel">Hannelore Daniel</name>
</noRegion>
<name sortKey="Blaut, Michael" sort="Blaut, Michael" uniqKey="Blaut M" first="Michael" last="Blaut">Michael Blaut</name>
<name sortKey="Clavel, Thomas" sort="Clavel, Thomas" uniqKey="Clavel T" first="Thomas" last="Clavel">Thomas Clavel</name>
<name sortKey="Clavel, Thomas" sort="Clavel, Thomas" uniqKey="Clavel T" first="Thomas" last="Clavel">Thomas Clavel</name>
<name sortKey="Desmarchelier, Charles" sort="Desmarchelier, Charles" uniqKey="Desmarchelier C" first="Charles" last="Desmarchelier">Charles Desmarchelier</name>
<name sortKey="Gholami, Amin Moghaddas" sort="Gholami, Amin Moghaddas" uniqKey="Gholami A" first="Amin Moghaddas" last="Gholami">Amin Moghaddas Gholami</name>
<name sortKey="Hahne, Hannes" sort="Hahne, Hannes" uniqKey="Hahne H" first="Hannes" last="Hahne">Hannes Hahne</name>
<name sortKey="Haller, Dirk" sort="Haller, Dirk" uniqKey="Haller D" first="Dirk" last="Haller">Dirk Haller</name>
<name sortKey="Kuster, Bernhard" sort="Kuster, Bernhard" uniqKey="Kuster B" first="Bernhard" last="Kuster">Bernhard Kuster</name>
<name sortKey="Kuster, Bernhard" sort="Kuster, Bernhard" uniqKey="Kuster B" first="Bernhard" last="Kuster">Bernhard Kuster</name>
<name sortKey="Loh, Gunnar" sort="Loh, Gunnar" uniqKey="Loh G" first="Gunnar" last="Loh">Gunnar Loh</name>
<name sortKey="Rothballer, Michael" sort="Rothballer, Michael" uniqKey="Rothballer M" first="Michael" last="Rothballer">Michael Rothballer</name>
<name sortKey="Schmitt Kopplin, Philippe" sort="Schmitt Kopplin, Philippe" uniqKey="Schmitt Kopplin P" first="Philippe" last="Schmitt-Kopplin">Philippe Schmitt-Kopplin</name>
<name sortKey="Walker, Alesia" sort="Walker, Alesia" uniqKey="Walker A" first="Alesia" last="Walker">Alesia Walker</name>
<name sortKey="Wenning, Mareike" sort="Wenning, Mareike" uniqKey="Wenning M" first="Mareike" last="Wenning">Mareike Wenning</name>
</country>
<country name="Autriche"><noRegion><name sortKey="Berry, David" sort="Berry, David" uniqKey="Berry D" first="David" last="Berry">David Berry</name>
</noRegion>
<name sortKey="Bohm, Christoph" sort="Bohm, Christoph" uniqKey="Bohm C" first="Christoph" last="Böhm">Christoph Böhm</name>
<name sortKey="Wagner, Michael" sort="Wagner, Michael" uniqKey="Wagner M" first="Michael" last="Wagner">Michael Wagner</name>
</country>
<country name="France"><noRegion><name sortKey="Mondot, Stanislas" sort="Mondot, Stanislas" uniqKey="Mondot S" first="Stanislas" last="Mondot">Stanislas Mondot</name>
</noRegion>
<name sortKey="Lepage, Patricia" sort="Lepage, Patricia" uniqKey="Lepage P" first="Patricia" last="Lepage">Patricia Lepage</name>
</country>
<country name="Australie"><noRegion><name sortKey="Mondot, Stanislas" sort="Mondot, Stanislas" uniqKey="Mondot S" first="Stanislas" last="Mondot">Stanislas Mondot</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004662 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004662 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:3906816
   |texte=   High-fat diet alters gut microbiota physiology in mice
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:24030595" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a AustralieFrV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

Serveur d'exploration sur les relations entre la France et l'Australie

High-fat diet alters gut microbiota physiology in mice

High-fat diet alters gut microbiota physiology in mice

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.